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Hepatitis C coinfection and extrahepatic cancer incidence among people living with HIV.

Authors :
Willis SJ
Kim HN
Achenbach CJ
Cachay ER
Christopoulos KA
Crane HM
Franco RA
Hurt CB
Kitahata MM
Moore RD
Silverberg MJ
Tien PC
Westreich D
Marcus JL
Source :
HIV medicine [HIV Med] 2022 Jul; Vol. 23 (6), pp. 620-628. Date of Electronic Publication: 2021 Dec 23.
Publication Year :
2022

Abstract

Objectives: We assessed the incidence of extrahepatic cancer among people with HIV/HCV coinfection and the potential impact of direct-acting antivirals (DAAs) on extrahepatic cancer risk among people with HIV/HCV coinfection.<br />Design: Our study cohort included adults who initiated HIV care at a CNICS site in the US during 1995-2017, excluding those with previous cancer and without HCV testing.<br />Methods: We used Cox regression to estimate hazard ratios for extrahepatic cancer incidence among patients with HIV/HCV coinfection compared with those with HIV monoinfection. Standardized morbidity ratio (SMR) weights were used to create a 'pseudopopulation' in which all patients were treated with antiretroviral therapy (ART), and to compare extrahepatic cancer incidence among patients with untreated HIV/HCV coinfection with the incidence that would have been observed if they had been successfully treated for HCV.<br />Results: Of 18 422 adults, 1775 (10%) had HCV RNA and 10 899 (59%) were on ART at baseline. Incidence rates of any extrahepatic cancer among patients with HIV/HCV coinfection and HIV monoinfection were 1027 and 771 per 100 000 person-years, respectively. In SMR-weighted analyses, the risk of any extrahepatic cancer among patients with untreated HCV coinfection at baseline was similar to the risk if they had been successfully treated for HCV. Patients with untreated HCV coinfection at baseline had higher incidence of kidney, lung and inflammation-related cancers than if their HCV had been successfully treated, but these associations were not statistically significant.<br />Conclusions: We did not find evidence that treating HCV coinfection with DAAs would reduce the incidence of extrahepatic cancers among people with HIV receiving ART.<br /> (© 2021 British HIV Association.)

Details

Language :
English
ISSN :
1468-1293
Volume :
23
Issue :
6
Database :
MEDLINE
Journal :
HIV medicine
Publication Type :
Academic Journal
Accession number :
34951105
Full Text :
https://doi.org/10.1111/hiv.13218