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Small Extracellular Vesicles Derived from Human Chorionic MSCs as Modern Perspective towards Cell-Free Therapy.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 18; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 18. - Publication Year :
- 2021
-
Abstract
- Mesenchymal stem cells (MSCs) are of great interest to scientists due to their application in cell therapy of many diseases, as well as regenerative medicine and tissue engineering. Recently, there has been growing evidence surrounding the research based on extracellular vesicles (EVs), especially small EVs (sEVs)/exosomes derived from MSCs. EVs/exosomes can be secreted by almost all cell types and various types of EVs show multiple functions. In addition, MSCs-derived exosomes have similar characteristics and biological activities to MSCs and their therapeutic applications are considered as a safe strategy in cell-free therapy. The aim of this study was the characterization of MSCs isolated from the chorion (CHo-MSCs) of human full-term placenta, as well as the isolation and analysis of small EVs obtained from these cells. Accordingly, in this study, the ability of small EVs' uptake is indicated by synovial fibroblasts, osteoblasts and periosteum-derived MSCs. Improvement in the understanding of the structure, characteristics, mechanism of action and potential application of MSCs-derived small EVs can provide new insight into improved therapeutic strategies.
- Subjects :
- Cell Communication
Cell- and Tissue-Based Therapy
Cells, Cultured
Chorion metabolism
Fibroblasts cytology
Fibroblasts metabolism
Humans
Mesenchymal Stem Cells metabolism
Osteoblasts cytology
Osteoblasts metabolism
Chorion cytology
Extracellular Vesicles metabolism
Mesenchymal Stem Cells cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 22
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 34948379
- Full Text :
- https://doi.org/10.3390/ijms222413581