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Effects of Specific Inhibitors for CaMK1D on a Primary Neuron Model for Alzheimer's Disease.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2021 Dec 18; Vol. 26 (24). Date of Electronic Publication: 2021 Dec 18. - Publication Year :
- 2021
-
Abstract
- Alzheimer's disease (AD) is the most common cause of dementia worldwide. Despite extensive research and targeting of the main molecular components of the disease, beta-amyloid (Aβ) and tau, there are currently no treatments that alter the progression of the disease. Here, we examine the effects of two specific kinase inhibitors for calcium/calmodulin-dependent protein kinase type 1D (CaMK1D) on Aβ-mediated toxicity, using mouse primary cortical neurons. Tau hyperphosphorylation and cell death were used as AD indicators. These specific inhibitors were found to prevent Aβ induced tau hyperphosphorylation in culture, but were not able to protect cells from Aβ induced toxicity. While inhibitors were able to alter AD pathology in cell culture, they were insufficient to prevent cell death. With further research and development, these inhibitors could contribute to a multi-drug strategy to combat AD.
- Subjects :
- Alzheimer Disease metabolism
Alzheimer Disease pathology
Amyloid beta-Peptides antagonists & inhibitors
Amyloid beta-Peptides metabolism
Animals
Calcium-Calmodulin-Dependent Protein Kinase Type 1 metabolism
Cell Survival drug effects
Cells, Cultured
Mice
Mice, Inbred BALB C
Models, Molecular
Neurons metabolism
Neurons pathology
Protein Kinase Inhibitors chemistry
Alzheimer Disease drug therapy
Calcium-Calmodulin-Dependent Protein Kinase Type 1 antagonists & inhibitors
Disease Models, Animal
Neurons drug effects
Protein Kinase Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 26
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 34946752
- Full Text :
- https://doi.org/10.3390/molecules26247669