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Chlovalicin B, a Chlorinated Sesquiterpene Isolated from the Marine Mushroom Digitatispora marina .
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2021 Dec 13; Vol. 26 (24). Date of Electronic Publication: 2021 Dec 13. - Publication Year :
- 2021
-
Abstract
- As part of our search for bioactive metabolites from understudied marine microorganisms, the new chlorinated metabolite chlovalicin B ( 1 ) was isolated from liquid cultures of the marine basidiomycete Digitatispora marina , which was collected and isolated from driftwood found at Vannøya, Norway. The structure of the novel compound was elucidated by spectroscopic methods including 1D and 2D NMR and analysis of HRMS data, revealing that 1 shares its molecular scaffold with a previously isolated compound, chlovalicin. This represents the first compound isolated from the Digitatispora genus, and the first reported fumagillin/ovalicin-like compound isolated from Basidiomycota. Compound 1 was evaluated for antibacterial activities against a panel of five bacteria, its ability to inhibit bacterial biofilm formation, for antifungal activity against Candida albicans , and for cytotoxic activities against malignant and non-malignant human cell lines. Compound 1 displayed weak cytotoxic activity against the human melanoma cell line A2058 (~50% survival at 50 µM). No activity was detected against biofilm formation or C. albicans at 50 µM, or against bacterial growth at 100 µM nor against the production of cytokines by the human acute monocytic leukemia cell line THP-1 at 50 µM.
- Subjects :
- Cyclohexanones chemistry
Cyclohexanones isolation & purification
Cyclohexanones pharmacology
Epoxy Compounds chemistry
Epoxy Compounds isolation & purification
Epoxy Compounds pharmacology
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents isolation & purification
Anti-Bacterial Agents pharmacology
Antifungal Agents chemistry
Antifungal Agents isolation & purification
Antifungal Agents pharmacology
Bacteria growth & development
Basidiomycota chemistry
Candida albicans growth & development
Sesquiterpenes chemistry
Sesquiterpenes isolation & purification
Sesquiterpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 26
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 34946641
- Full Text :
- https://doi.org/10.3390/molecules26247560