Back to Search
Start Over
Diet-induced weight loss in obese/diabetic mice normalizes glucose metabolism and promotes functional recovery after stroke.
- Source :
-
Cardiovascular diabetology [Cardiovasc Diabetol] 2021 Dec 22; Vol. 20 (1), pp. 240. Date of Electronic Publication: 2021 Dec 22. - Publication Year :
- 2021
-
Abstract
- Background: Post-stroke functional recovery is severely impaired by type 2 diabetes (T2D). This is an important clinical problem since T2D is one of the most common diseases. Because weight loss-based strategies have been shown to decrease stroke risk in people with T2D, we aimed to investigate whether diet-induced weight loss can also improve post-stroke functional recovery and identify some of the underlying mechanisms.<br />Methods: T2D/obesity was induced by 6 months of high-fat diet (HFD). Weight loss was achieved by a short- or long-term dietary change, replacing HFD with standard diet for 2 or 4 months, respectively. Stroke was induced by middle cerebral artery occlusion and post-stroke recovery was assessed by sensorimotor tests. Mechanisms involved in neurovascular damage in the post-stroke recovery phase, i.e. neuroinflammation, impaired angiogenesis and cellular atrophy of GABAergic parvalbumin (PV)+ interneurons were assessed by immunohistochemistry/quantitative microscopy.<br />Results: Both short- and long-term dietary change led to similar weight loss. However, only the latter enhanced functional recovery after stroke. This effect was associated with pre-stroke normalization of fasting glucose and insulin resistance, and with the reduction of T2D-induced cellular atrophy of PV+ interneurons. Moreover, stroke recovery was associated with decreased T2D-induced neuroinflammation and reduced astrocyte reactivity in the contralateral striatum.<br />Conclusion: The global diabetes epidemic will dramatically increase the number of people in need of post-stroke treatment and care. Our results suggest that diet-induced weight loss leading to pre-stroke normalization of glucose metabolism has great potential to reduce the sequelae of stroke in the diabetic population.<br /> (© 2021. The Author(s).)
- Subjects :
- Animals
Behavior, Animal
Biomarkers blood
Brain metabolism
Brain pathology
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 physiopathology
Diet, High-Fat
Disease Models, Animal
Glycemic Control
Infarction, Middle Cerebral Artery blood
Infarction, Middle Cerebral Artery pathology
Infarction, Middle Cerebral Artery physiopathology
Male
Mice, Inbred C57BL
Obesity blood
Obesity physiopathology
Recovery of Function
Stroke blood
Stroke pathology
Stroke physiopathology
Time Factors
Mice
Blood Glucose metabolism
Brain physiopathology
Diabetes Mellitus, Type 2 diet therapy
Infarction, Middle Cerebral Artery diet therapy
Obesity diet therapy
Stroke diet therapy
Weight Loss
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2840
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cardiovascular diabetology
- Publication Type :
- Academic Journal
- Accession number :
- 34937562
- Full Text :
- https://doi.org/10.1186/s12933-021-01426-z