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Effects of nitric oxide modulators and antioxidants on endocrine and cellular markers of acute stress in rats.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Jan 22; Vol. 589, pp. 234-239. Date of Electronic Publication: 2021 Dec 15. - Publication Year :
- 2022
-
Abstract
- The effects of nitric oxide modulators (NO-modulators) and antioxidants on acute (RSx1) restraint stress induced endocrine, cellular and oxidative/nitrosative stress markers was studied in Wistar rats. The results of our study revealed that exposure to RS(x1) enhanced malondialdehyde (MDA), heat shock protein (HSP-70), corticosterone, nuclear factor kappa B (NF-κB) levels and suppressed glutathione (GSH), superoxide dismutase (SOD) and total nitrites and nitrates (NOx) levels. NO precursor and NO synthase inhibitors were found to differentially modulate stress mechanisms, by altering NF-κB, HSP-70 and corticosterone levels. l-Ascorbic acid significantly suppressed acute stress induced elevation of NF-κB and HSP-70 levels depicting protective effects, as also evidenced by reversal of elevated plasma corticosterone levels. Therefore, modulation of oxidative and nitrosative pathways, offers an approach in modulating stress induced changes associated with various disorders.<br />Competing Interests: Declaration of competing interest None.<br /> (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Subjects :
- Acute Disease
Animals
Arginine pharmacology
Corticosterone blood
Female
Glutathione metabolism
HSP70 Heat-Shock Proteins metabolism
Male
Malondialdehyde metabolism
NF-kappa B metabolism
Nitrates metabolism
Nitric Oxide Synthase antagonists & inhibitors
Nitric Oxide Synthase metabolism
Nitrites metabolism
Rats, Wistar
Restraint, Physical
Stress, Psychological blood
Superoxide Dismutase metabolism
Rats
Antioxidants pharmacology
Biomarkers metabolism
Endocrine System metabolism
Nitric Oxide metabolism
Stress, Psychological metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 589
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 34933198
- Full Text :
- https://doi.org/10.1016/j.bbrc.2021.12.035