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Antitumor activity of an immunotoxin in a nude mouse model of human ovarian cancer.
- Source :
-
Cancer research [Cancer Res] 1987 Mar 01; Vol. 47 (5), pp. 1407-10. - Publication Year :
- 1987
-
Abstract
- An immunotoxin composed of an antibody to the human transferrin receptor (454A12) and ricin A chain (RTA) was shown to inhibit the growth of NIH:OVCAR-3 tumors in a nude mouse model of human ovarian cancer. Inhibition of tumor growth by 454A12-RTA was related to the dose administered. The antitumor activity of the immunotoxin was blocked by coinjection of excess antibody with immunotoxin. An immunotoxin made using 454A12 and recombinant ricin A chain (rRTA) had an activity similar to that made with native RTA. The administration of 10 micrograms or greater of the immunotoxin 454A12-RTA/rRTA had significant antitumor activity. The injection of 30 micrograms of an irrelevant immunotoxin, MOPC21-RTA, or 30 to 500 micrograms of the 454A12 antibody had no antitumor activity.
- Subjects :
- Animals
Cell Line
Dose-Response Relationship, Drug
Female
Humans
Mice
Mice, Nude
Neoplasm Invasiveness
Neoplasm Transplantation
Ovarian Neoplasms pathology
Transplantation, Heterologous
Immunotoxins therapeutic use
Ovarian Neoplasms therapy
Receptors, Transferrin immunology
Ricin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0008-5472
- Volume :
- 47
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cancer research
- Publication Type :
- Academic Journal
- Accession number :
- 3493065