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Guanine-Based G-Quadruplexes Templated by Various Cations toward Potential Use as Single-Ion Conductors.
- Source :
-
ChemSusChem [ChemSusChem] 2022 Feb 18; Vol. 15 (4), pp. e202102201. Date of Electronic Publication: 2022 Jan 20. - Publication Year :
- 2022
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Abstract
- Inspired by the atomic-sized, shape-regulated features of G-quadruplexes comprising guanine motifs with a monovalent metal cation, the G-quadruplex-forming ability, and properties of a guanine-based π-conjugated Y2 molecule containing bithiophene and peripheral dodecyl chain units in the presence of various cation salts (Li <superscript>+</superscript> , Na <superscript>+</superscript> , K <superscript>+</superscript> , and Mg <superscript>2+</superscript> ) were exploited. A series of structural characterization revealed that Y2 yielded desirable G-quadruplexes with all the tested cations as a consequence of the combination of a hydrogen-bonded cyclic G-quartet, π-stacking, and cation-dipole interactions. The radius and nature of the coordinating cations crucially affected the structural characteristics of G-quadruplexes, leading to variations in the ion migration ability inside the cavity of the G-quadruplex (Li <superscript>+</superscript> >Na <superscript>+</superscript> >K <superscript>+</superscript> >Mg <superscript>2+</superscript> ), as characterized through theoretical and experimental investigations. These results not only improve the understanding of G-quadruplex self-assemblies based on guanine but also provide an impetus for their diverse potential applications, especially in the field of Li batteries.<br /> (© 2021 Wiley-VCH GmbH.)
Details
- Language :
- English
- ISSN :
- 1864-564X
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- ChemSusChem
- Publication Type :
- Academic Journal
- Accession number :
- 34929057
- Full Text :
- https://doi.org/10.1002/cssc.202102201