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Inter-individual differences in pain anticipation and pain perception in migraine: Neural correlates of migraine frequency and cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio.
- Source :
-
PloS one [PLoS One] 2021 Dec 20; Vol. 16 (12), pp. e0261570. Date of Electronic Publication: 2021 Dec 20 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Previous studies targeting inter-individual differences in pain processing in migraine mainly focused on the perception of pain. Our main aim was to disentangle pain anticipation and perception using a classical fear conditioning task, and investigate how migraine frequency and pre-scan cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio as an index of neurobiological stress response would relate to neural activation in these two phases. Functional Magnetic Resonance Imaging (fMRI) data of 23 participants (18 females; mean age: 27.61± 5.36) with episodic migraine without aura were analysed. We found that migraine frequency was significantly associated with pain anticipation in brain regions comprising the midcingulate and caudate, whereas pre-scan cortisol-to DHEA-S ratio was related to pain perception in the pre-supplementary motor area (pre-SMA). Both results suggest exaggerated preparatory responses to pain or more general to stressors, which may contribute to the allostatic load caused by stressors and migraine attacks on the brain.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Adult
Brain diagnostic imaging
Brain metabolism
Brain Chemistry
Dehydroepiandrosterone Sulfate analysis
Female
Functional Neuroimaging
Humans
Hydrocortisone analysis
Individuality
Magnetic Resonance Imaging
Male
Migraine Disorders epidemiology
Young Adult
Dehydroepiandrosterone Sulfate metabolism
Hydrocortisone metabolism
Migraine Disorders psychology
Pain Perception
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 16
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 34929017
- Full Text :
- https://doi.org/10.1371/journal.pone.0261570