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RCC1 Expression as a Prognostic Marker in Colorectal Liver Oligometastases.
- Source :
-
Pathology oncology research : POR [Pathol Oncol Res] 2021 Dec 02; Vol. 27, pp. 1610077. Date of Electronic Publication: 2021 Dec 02 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Introduction: Regulator of chromatin condensation 1 (RCC1) is a major guanine-nucleotide exchange factor for Ran GTPase, and it plays key roles in various biological processes. Previous studies have found that RCC1 may play a role in the development of tumors, but little is known about the relationship between RCC1 and colorectal liver oligometastases (CLOs). Methods: One hundred and twenty-nine pairs of matched human CLO samples, including both primary tumor and its liver metastasis specimens, were subjected to immunohistochemistry to determine the location and expression levels of RCC1. Associations between RCC1 and survival as well as gene expression profiling were explored. Results: In this study, we first observed that RCC1 was mildly increased in CLO tumor tissues compared with normal tissues, and the localization was primarily nuclear. In addition, our study found that high RCC1 expression in liver oligometastases was an independent prognostic marker for unfavorable recurrence-free survival and overall survival ( p = 0.036 and p = 0.016). Gene expression profiles generated from microarray analysis showed that RCC1 was involved in pathways including "Myc targets," "E2F targets" and "DNA repair" pathways. Conclusion: Our data indicated that RCC1 was expressed mainly in the nucleus, and strong and significant associations were found between RCC1 expression levels and the survival of CLO patients. These findings indicated that RCC1 may play a role in CLO development.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Deng, Yu, Zhao, Peng, Xu, Qin, Xiao, Liu, Li, Fang and Pan.)
- Subjects :
- Adult
Aged
Biomarkers, Tumor metabolism
Cell Nucleus metabolism
Colorectal Neoplasms mortality
Colorectal Neoplasms pathology
Disease-Free Survival
Female
Gene Expression Profiling
Humans
Liver Neoplasms mortality
Liver Neoplasms secondary
Male
Middle Aged
Prognosis
Cell Cycle Proteins metabolism
Colorectal Neoplasms metabolism
Guanine Nucleotide Exchange Factors metabolism
Liver Neoplasms metabolism
Nuclear Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2807
- Volume :
- 27
- Database :
- MEDLINE
- Journal :
- Pathology oncology research : POR
- Publication Type :
- Academic Journal
- Accession number :
- 34924821
- Full Text :
- https://doi.org/10.3389/pore.2021.1610077