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Human papilloma virus infection of uterine cervix and spectrum of cervical pathology in human immunodeficiency virus/AIDS.
- Source :
-
Journal of cancer research and therapeutics [J Cancer Res Ther] 2021 Oct-Dec; Vol. 17 (6), pp. 1462-1467. - Publication Year :
- 2021
-
Abstract
- Background: Human papilloma virus (HPV) is one of the most common causes of sexually transmitted viral diseases worldwide. High-risk HPV types such as HPV16 and 18 are known to cause cervical dysplasia and carcinoma. In human immunodeficiency virus (HIV)-positive individual, chance of HPV coinfection and risk of cervical dysplasia/carcinoma have been found to be significantly more than in HIV-negative individuals.<br />Aim: In this institution-based, cross-sectional, observational study, we aim to find out the relationship of HPV infection of the uterine cervix with cervical dysplasia and neoplasia in HIV-infected/AIDS patients.<br />Materials and Methods: Conventional Pap smears were taken from HIV-infected individuals admitted in the department of gynecology and obstetrics and reported by the Bethesda system. A second sample was sent to the virology unit of ICMR for detection and typing of HPV. Control samples were taken from HIV-negative individuals.<br />Results: Fifty HIV-positive patients were included in this study. On cervical Pap smear examination, 32 cases were cytologically benign and 18 cases showed atypical cytomorphology. Twenty-four cases were HPV positive, among which 16 were cytologically atypical and 8 were benign. HPV 16 was the most common subtype (50%) followed by HPV 18 (37.5%) and others (12.5%) in HIV-positive patients. Chance of cervical dysplasia increased with age independent of HIV infection and with progressive lower CD4 count. Koilocytosis was a significant predictor of HPV infection. Majority of patients were asymptomatic. Peak incidence of HPV infection occurred in reproductive age group (20-40 years). The association between HIV and HPV coinfection (P = 0.002) and between HPV infection and cytology atypia (P < 0.0001) was statistically significant.<br />Conclusion: Present study highlights the necessity of routine cervical Pap smear screening in HIV infected reproductive age-group women. Early detection enables dysplasia to revert or be effectively managed.<br />Competing Interests: None
- Subjects :
- Adult
Cervix Uteri pathology
Cervix Uteri virology
Coinfection immunology
Coinfection pathology
Coinfection virology
Cross-Sectional Studies
Female
HIV Infections immunology
HIV Infections pathology
HIV Infections virology
Human papillomavirus 16 immunology
Human papillomavirus 16 isolation & purification
Human papillomavirus 18 immunology
Human papillomavirus 18 isolation & purification
Humans
Incidence
Middle Aged
Papanicolaou Test statistics & numerical data
Papillomavirus Infections immunology
Papillomavirus Infections pathology
Papillomavirus Infections virology
Uterine Cervical Neoplasms immunology
Uterine Cervical Neoplasms pathology
Uterine Cervical Neoplasms virology
Vaginal Smears statistics & numerical data
Young Adult
Uterine Cervical Dysplasia immunology
Uterine Cervical Dysplasia pathology
Uterine Cervical Dysplasia virology
Coinfection epidemiology
HIV Infections complications
Papillomavirus Infections epidemiology
Uterine Cervical Neoplasms epidemiology
Uterine Cervical Dysplasia epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1998-4138
- Volume :
- 17
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of cancer research and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 34916378
- Full Text :
- https://doi.org/10.4103/jcrt.JCRT_552_19