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Comparison of 11 C-Pittsburgh Compound B and 18 F-Flutemetamol White Matter Binding in PET.
- Source :
-
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2022 Aug; Vol. 63 (8), pp. 1239-1244. Date of Electronic Publication: 2021 Dec 16. - Publication Year :
- 2022
-
Abstract
- PET imaging with β-amyloid ligands is emerging as a molecular imaging technique targeting white matter integrity and demyelination. β-amyloid PET ligands such as <superscript>11</superscript> C-Pittsburgh compound B ( <superscript>11</superscript> C-PiB) have been considered for quantitative measurement of myelin content changes in multiple sclerosis, but <superscript>11</superscript> C-PiB is not commercially available given its short half-life. A <superscript>18</superscript> F PET ligand such as flutemetamol with a longer half-life may be an alternative, but its ability to differentiate white matter hyperintensities (WMH) from normal-appearing white matter (NAWM) and its relationship with age remains to be investigated. Methods: Cognitively unimpaired (CU) older and younger adults ( n = 61) were recruited from the community responding to a study advertisement for β-amyloid PET. Participants prospectively underwent MRI, <superscript>11</superscript> C-PiB, and <superscript>18</superscript> F-flutemetamol PET scans. MRI fluid-attenuated inversion recovery images were segmented into WMH and NAWM and registered to the T1-weighted MRI. <superscript>11</superscript> C-PiB and <superscript>18</superscript> F-flutemetamol PET images were also registered to the T1-weighted MRI. <superscript>11</superscript> C-PiB and <superscript>18</superscript> F-flutemetamol SUV ratios (SUVrs) from the WMH and NAWM were calculated using cerebellar crus uptake as a reference for both <superscript>11</superscript> C-PiB and <superscript>18</superscript> F-flutemetamol. Results: The median age was 38 y (range, 30-48 y) in younger adults and 67 y (range, 61-83 y) in older adults. WMH and NAWM SUVrs were higher with <superscript>18</superscript> F-flutemetamol than with <superscript>11</superscript> C-PiB in both older ( P < 0.001) and younger ( P < 0.001) CU adults. <superscript>11</superscript> C-PiB and <superscript>18</superscript> F-flutemetamol SUVrs were higher in older than in younger CU adults in both WMH ( P < 0.001) and NAWM ( P < 0.001). <superscript>11</superscript> C-PiB and <superscript>18</superscript> F-flutemetamol SUVrs were higher in NAWM than WMH in both older ( P < 0.001) and younger ( P < 0.001) CU adults. There was no apparent difference between <superscript>11</superscript> C-PiB and <superscript>18</superscript> F-flutemetamol SUVrs in differentiating WMH from NAWM in older and in younger adults. Conclusion: <superscript>11</superscript> C-PiB and <superscript>18</superscript> F-flutemetamol show a similar topographic pattern of uptake in white matter with a similar association with age in WMH and NAWM. <superscript>11</superscript> C-PiB and <superscript>18</superscript> F-flutemetamol can also effectively distinguish between WMH and NAWM. However, given its longer half-life, commercial availability, and higher binding potential, <superscript>18</superscript> F-flutemetamol can be an alternative to <superscript>11</superscript> C-PiB in molecular imaging studies specifically targeting multiple sclerosis to evaluate white matter integrity.<br /> (© 2022 by the Society of Nuclear Medicine and Molecular Imaging.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Amyloid beta-Peptides metabolism
Aniline Compounds metabolism
Benzothiazoles metabolism
Brain diagnostic imaging
Brain metabolism
Humans
Middle Aged
Positron-Emission Tomography methods
Thiazoles
Alzheimer Disease metabolism
Multiple Sclerosis metabolism
White Matter diagnostic imaging
White Matter metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1535-5667
- Volume :
- 63
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 34916245
- Full Text :
- https://doi.org/10.2967/jnumed.121.263281