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Endothelial injury in COVID-19 and septic patients.
- Source :
-
Microvascular research [Microvasc Res] 2022 Mar; Vol. 140, pp. 104303. Date of Electronic Publication: 2021 Dec 13. - Publication Year :
- 2022
-
Abstract
- Systemic inflammatory response, as observed in sepsis and severe COVID-19, may lead to endothelial damage. Therefore, we aim to compare the extent of endothelial injury and its relationship to inflammation in both diseases. We included patients diagnosed with sepsis (SEPSIS group, n = 21), mild COVID-19 (MILD group, n = 31), and severe COVID-19 (SEVERE group, n = 24). Clinical and routine laboratory data were obtained, circulating cytokines (INF-γ, TNF-α, and IL-10) and endothelial injury markers (E-Selectin, Tissue Factor (TF) and von Willebrand factor (vWF)) were measured. Compared to the SEPSIS group, patients with severe COVID-19 present similar clinical and laboratory data, except for lower circulating IL-10 and E-Selectin levels. Compared to the MILD group, patients in the SEVERE group showed higher levels of TNF-α, IL-10, and TF. There was no clear relationship between cytokines and endothelial injury markers among the three studied groups; however, in SEVERE COVID-19 patients, there is a positive relationship between INF-γ with TF and a negative relationship between IL-10 and vWF. In conclusion, COVID-19 and septic patients have a similar pattern of cytokines and endothelial dysfunction markers. These findings highlight the importance of endothelium dysfunction in COVID-19 and suggest that endothelium should be better evaluated as a therapeutic target for the disease.<br /> (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Biomarkers
Blood Cell Count
C-Reactive Protein analysis
COVID-19 blood
COVID-19 complications
COVID-19 physiopathology
E-Selectin blood
Female
Humans
Interferon-gamma blood
Interleukin-10 blood
Male
Middle Aged
Retrospective Studies
Sepsis blood
Sepsis complications
Sepsis physiopathology
Severity of Illness Index
Systemic Inflammatory Response Syndrome etiology
Systemic Inflammatory Response Syndrome physiopathology
Thromboplastin analysis
Tumor Necrosis Factor-alpha analysis
von Willebrand Factor analysis
COVID-19 pathology
Endothelium, Vascular pathology
SARS-CoV-2
Sepsis pathology
Systemic Inflammatory Response Syndrome blood
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9319
- Volume :
- 140
- Database :
- MEDLINE
- Journal :
- Microvascular research
- Publication Type :
- Academic Journal
- Accession number :
- 34914941
- Full Text :
- https://doi.org/10.1016/j.mvr.2021.104303