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Towards CRISPR powered electrochemical sensing for smart diagnostics.
- Source :
-
Current opinion in electrochemistry [Curr Opin Electrochem] 2021 Dec; Vol. 30, pp. 100829. Date of Electronic Publication: 2021 Aug 12. - Publication Year :
- 2021
-
Abstract
- Even though global health has been steadily improved, the global disease burden associated with communicable and non-communicable diseases extensively increased healthcare expenditure. The present COVID-19 pandemic scenario has again ascertained the importance of clinical diagnostics as a basis to make life-saving decisions. In this context, there is a need for developing next-generation integrated smart real-time responsive biosensors with high selectivity and sensitivity. The emergence of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas biosensing systems has shown remarkable potential for developing next-generation biosensors. CRISPR/Cas integrated electrochemical biosensors (E-CRISPR) stands out with excellent properties. In this opinionated review, we illustrate the rapidly evolving applications for E-CRISPR-integrated detection systems towards biosensing and the future scope associated with E-CRISPR based diagnostics.<br />Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (© 2021 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 2451-9103
- Volume :
- 30
- Database :
- MEDLINE
- Journal :
- Current opinion in electrochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 34909513
- Full Text :
- https://doi.org/10.1016/j.coelec.2021.100829