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Brain functional connectivity in patients with hyperthyroidism after anti-thyroid treatment.
- Source :
-
Journal of neuroendocrinology [J Neuroendocrinol] 2022 Jan; Vol. 34 (1), pp. e13075. Date of Electronic Publication: 2021 Dec 14. - Publication Year :
- 2022
-
Abstract
- Thyroid disease is known to affect brain metabolism and cognitive function, although the recovery of thyroid-induced brain functional changes after treatment remains unclear. We aimed to investigate the alteration in brain functional connectivity and its correlation with neuropsychological variables in hyperthyroid patients before and after anti-thyroid treatment using a resting-state functional magnetic resonance imaging (rsfMRI) technique. This is a follow-up rsfMRI study of previous work that showed impaired brain functional connectivity in hyperthyroid patients compared to healthy controls. We included rsfMRI and neuropsychological data from 21 hyperthyroid patients out of an original cohort of 28 patients, before and after anti-thyroid treatment for 30 weeks. Functional connectivity analysis and neuropsychological scores were compared using paired t tests in patients at baseline and at follow-up. Patients showed an improvement in some of the memory (p < .05) and executive, visuospatial and motor (p < .001) functions after treatment, and also showed increased functional connectivity in the regions of the right fronto-parietal network, left fronto-parietal network, and default mode network (DMN) (p < .05). At follow-up, the functional connectivity of the right fronto-parietal network showed a significantly positive correlation with the recognition of objects memory score. The overall findings suggest that anti-thyroid treatment with carbimazole improves the functional connectivity within some of the resting state networks in the hyperthyroid patients, whereas the remaining networks still show impairment.<br /> (© 2021 British Society for Neuroendocrinology.)
- Subjects :
- Adult
Brain cytology
Brain diagnostic imaging
Brain Mapping
Carbimazole therapeutic use
Cognition drug effects
Cohort Studies
Executive Function drug effects
Female
Humans
Hyperthyroidism diagnosis
Hyperthyroidism physiopathology
Hyperthyroidism psychology
India
Magnetic Resonance Imaging
Male
Middle Aged
Neural Pathways diagnostic imaging
Neuropsychological Tests
Antithyroid Agents therapeutic use
Brain drug effects
Hyperthyroidism drug therapy
Neural Pathways drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2826
- Volume :
- 34
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of neuroendocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 34905237
- Full Text :
- https://doi.org/10.1111/jne.13075