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Head-to-Tail Cross-Linking to Generate Bicyclic Helical Peptides with Enhanced Helicity and Proteolytic Stability.
- Source :
-
Organic letters [Org Lett] 2022 Jan 14; Vol. 24 (1), pp. 53-57. Date of Electronic Publication: 2021 Dec 12. - Publication Year :
- 2022
-
Abstract
- We report a new pattern of a bicyclic helical peptide constructed through head-to-tail cross-linking. The described bicyclic helical peptide has a head-to-tail cross-linking arm and a C-terminal i , i + 4 cross-linking arm. This scaffold will provide a promising scaffold for designing a proteolytically resistant helix-constrained peptide.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 34894695
- Full Text :
- https://doi.org/10.1021/acs.orglett.1c03629