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Head-to-Tail Cross-Linking to Generate Bicyclic Helical Peptides with Enhanced Helicity and Proteolytic Stability.

Authors :
Chen K
Tang Y
Wu M
Wan XC
Zhang YN
Chen XX
Yu FQ
Cui ZH
Ma JM
Zhou Z
Fang GM
Source :
Organic letters [Org Lett] 2022 Jan 14; Vol. 24 (1), pp. 53-57. Date of Electronic Publication: 2021 Dec 12.
Publication Year :
2022

Abstract

We report a new pattern of a bicyclic helical peptide constructed through head-to-tail cross-linking. The described bicyclic helical peptide has a head-to-tail cross-linking arm and a C-terminal i , i + 4 cross-linking arm. This scaffold will provide a promising scaffold for designing a proteolytically resistant helix-constrained peptide.

Details

Language :
English
ISSN :
1523-7052
Volume :
24
Issue :
1
Database :
MEDLINE
Journal :
Organic letters
Publication Type :
Academic Journal
Accession number :
34894695
Full Text :
https://doi.org/10.1021/acs.orglett.1c03629