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Clinical translation of advanced colonic drug delivery technologies.
- Source :
-
Advanced drug delivery reviews [Adv Drug Deliv Rev] 2022 Feb; Vol. 181, pp. 114076. Date of Electronic Publication: 2021 Dec 07. - Publication Year :
- 2022
-
Abstract
- Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local diseases, direct access to unique therapeutic targets and the potential for increasing systemic drug bioavailability and efficacy. Although a range of traditional colonic delivery technologies are available, these systems exhibit inconsistent drug release due to physiological variability between and within individuals, which may be further exacerbated by underlying disease states. In recent years, significant translational and commercial advances have been made with the introduction of new technologies that incorporate independent multi-stimuli release mechanisms (pH and/or microbiota-dependent release). Harnessing these advanced technologies offers new possibilities for drug delivery via the colon, including the delivery of biopharmaceuticals, vaccines, nutrients, and microbiome therapeutics for the treatment of both local and systemic diseases. This review details the latest advances in colonic drug delivery, with an emphasis on emerging therapeutic opportunities and clinical technology translation.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2021. Published by Elsevier B.V.)
- Subjects :
- Biological Products administration & dosage
Delayed-Action Preparations
Gastrointestinal Microbiome physiology
Gastrointestinal Transit physiology
Humans
Hydrogen-Ion Concentration
Irritable Bowel Syndrome drug therapy
Prebiotics administration & dosage
Printing, Three-Dimensional
Probiotics administration & dosage
Time Factors
Vaccines administration & dosage
Colon drug effects
Colon physiology
Drug Delivery Systems methods
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8294
- Volume :
- 181
- Database :
- MEDLINE
- Journal :
- Advanced drug delivery reviews
- Publication Type :
- Academic Journal
- Accession number :
- 34890739
- Full Text :
- https://doi.org/10.1016/j.addr.2021.114076