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Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets.
- Source :
-
Nature cell biology [Nat Cell Biol] 2021 Dec; Vol. 23 (12), pp. 1240-1254. Date of Electronic Publication: 2021 Dec 09. - Publication Year :
- 2021
-
Abstract
- Extracellular vesicles and exomere nanoparticles are under intense investigation as sources of clinically relevant cargo. Here we report the discovery of a distinct extracellular nanoparticle, termed supermere. Supermeres are morphologically distinct from exomeres and display a markedly greater uptake in vivo compared with small extracellular vesicles and exomeres. The protein and RNA composition of supermeres differs from small extracellular vesicles and exomeres. Supermeres are highly enriched with cargo involved in multiple cancers (glycolytic enzymes, TGFBI, miR-1246, MET, GPC1 and AGO2), Alzheimer's disease (APP) and cardiovascular disease (ACE2, ACE and PCSK9). The majority of extracellular RNA is associated with supermeres rather than small extracellular vesicles and exomeres. Cancer-derived supermeres increase lactate secretion, transfer cetuximab resistance and decrease hepatic lipids and glycogen in vivo. This study identifies a distinct functional nanoparticle replete with potential circulating biomarkers and therapeutic targets for a host of human diseases.<br /> (© 2022. The Author(s).)
- Subjects :
- Alzheimer Disease pathology
Angiotensin-Converting Enzyme 2 metabolism
Biological Transport physiology
Biomarkers metabolism
COVID-19 pathology
Cardiovascular Diseases pathology
Cell Communication physiology
Cell Line, Tumor
HeLa Cells
Humans
Lactic Acid metabolism
MicroRNAs genetics
Nanoparticles classification
Neoplasms pathology
Tumor Microenvironment
Extracellular Vesicles metabolism
MicroRNAs metabolism
Nanoparticles metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4679
- Volume :
- 23
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Nature cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 34887515
- Full Text :
- https://doi.org/10.1038/s41556-021-00805-8