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Alpha-to-beta cell trans-differentiation for treatment of diabetes.
- Source :
-
Biochemical Society transactions [Biochem Soc Trans] 2021 Dec 17; Vol. 49 (6), pp. 2539-2548. - Publication Year :
- 2021
-
Abstract
- Diabetes mellitus is a significant cause of morbidity and mortality in the United States and worldwide. According to the CDC, in 2017, ∼34.2 million of the American population had diabetes. Also, in 2017, diabetes was the seventh leading cause of death and has become the number one biomedical financial burden in the United States. Insulin replacement therapy and medications that increase insulin secretion and improve insulin sensitivity are the main therapies used to treat diabetes. Unfortunately, there is currently no radical cure for the different types of diabetes. Loss of β cell mass is the end result that leads to both type 1 and type 2 diabetes. In the past decade, there has been an increased effort to develop therapeutic strategies to replace the lost β cell mass and restore insulin secretion. α cells have recently become an attractive target for replacing the lost β cell mass, which could eventually be a potential strategy to cure diabetes. This review highlights the advantages of using α cells as a source for generating new β cells, the various investigative approaches to convert α cells into insulin-producing cells, and the future prospects and problems of this promising diabetes therapeutic strategy.<br /> (© 2021 The Author(s).)
- Subjects :
- Animals
Diabetes Mellitus, Type 1 pathology
Diabetes Mellitus, Type 2 pathology
Humans
Insulin metabolism
Insulin-Secreting Cells metabolism
Insulin-Secreting Cells pathology
Mice
Transcription Factors metabolism
Cell Transdifferentiation
Cell- and Tissue-Based Therapy
Diabetes Mellitus, Type 1 therapy
Diabetes Mellitus, Type 2 therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1470-8752
- Volume :
- 49
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Biochemical Society transactions
- Publication Type :
- Academic Journal
- Accession number :
- 34882233
- Full Text :
- https://doi.org/10.1042/BST20210244