Protective Effects of Mogroside V on Oxidative Stress Induced by H 2 O 2 in Skin Fibroblasts.

Purpose: Damage caused by oxidative stress leads to the premature aging of cells. Mogrosides, the main active components of Siraitia grosvenorii , have strong antioxidant activity; however, it is unclear whether mogroside V (MV) exerts these effects in skin cells. This was investigated in the present study by evaluating the protective effects of MV against oxidative damage induced by hydrogen peroxide (H ₂ O ₂ ) in skin fibroblasts.
Methods: Mouse skin fibroblasts (MSFs) were treated with H ₂ O ₂ and cell viability, total antioxidant capacity, reactive oxygen species (ROS) production, malondialdehyde (MDA) content, and antioxidant enzyme activity were assessed.
Results: Treatment with MV reduced the ROS level and MDA content in MSFs treated with H ₂ O ₂ . This was accompanied by increased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities.
Conclusion: MV reduces H ₂ O ₂ -induced oxidative stress and enhances endogenous antioxidant activity in skin fibroblasts. Thus, MV can potentially be used as an ingredient in anti-aging cosmetic products.
Competing Interests: Ms Qiuting Mo reports grants from the Research Foundation for Youth Scholars of Beijing Technology and Business University (QNJJ2020-04), during the conduct of the study. The authors report no other conflicts of interest in relation to this work.
(© 2021 Mo et al.)