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Multi-omics approach to COVID-19: a domain-based literature review.
- Source :
-
Journal of translational medicine [J Transl Med] 2021 Dec 07; Vol. 19 (1), pp. 501. Date of Electronic Publication: 2021 Dec 07. - Publication Year :
- 2021
-
Abstract
- Background: Omics data, driven by rapid advances in laboratory techniques, have been generated very quickly during the COVID-19 pandemic. Our aim is to use omics data to highlight the involvement of specific pathways, as well as that of cell types and organs, in the pathophysiology of COVID-19, and to highlight their links with clinical phenotypes of SARS-CoV-2 infection.<br />Methods: The analysis was based on the domain model, where for domain it is intended a conceptual repository, useful to summarize multiple biological pathways involved at different levels. The relevant domains considered in the analysis were: virus, pathways and phenotypes. An interdisciplinary expert working group was defined for each domain, to carry out an independent literature scoping review.<br />Results: The analysis revealed that dysregulated pathways of innate immune responses, (i.e., complement activation, inflammatory responses, neutrophil activation and degranulation, platelet degranulation) can affect COVID-19 progression and outcomes. These results are consistent with several clinical studies.<br />Conclusions: Multi-omics approach may help to further investigate unknown aspects of the disease. However, the disease mechanisms are too complex to be explained by a single molecular signature and it is necessary to consider an integrated approach to identify hallmarks of severity.<br /> (© 2021. The Author(s).)
- Subjects :
- Humans
Immunity, Innate
Pandemics
SARS-CoV-2
COVID-19
Subjects
Details
- Language :
- English
- ISSN :
- 1479-5876
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of translational medicine
- Publication Type :
- Academic Journal
- Accession number :
- 34876157
- Full Text :
- https://doi.org/10.1186/s12967-021-03168-8