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Design Strategy for a Hydroxide-Triggered pH-Responsive Hydrogel as a Mucoadhesive Barrier to Prevent Metabolism Disorders.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Dec 15; Vol. 13 (49), pp. 58340-58351. Date of Electronic Publication: 2021 Dec 06. - Publication Year :
- 2021
-
Abstract
- Excess nutrient uptake is one of the main factors of complications related to metabolism disorders. Therefore, efforts have emerged to modulate nutrient transport in the intestine. However, current approaches are mainly invasive interventions with various side effects. Here, a pH-responsive hydrogel is formulated by acidifying the hydroxide compounds within sucralfate to allow electrostatic interactions between pectin and aluminum ions. The pH responsiveness relies on the alternation of cations and hydroxide species, providing reversible shifting from a hydrogel to a complex coacervate system. It acts as a transient physical barrier coating to inhibit intestinal absorption and changes the viscosity and barrier function in different parts of the gastrointestinal tract, showing enhanced mucoadhesive properties. The therapeutic hydrogel remarkably lowers the immediate blood glucose response by modulating nutrient contact with bowel mucosa, suggesting potential in treating diabetes. In addition, it significantly reduces weight gain, fat accumulation, and hepatic lipid deposition in rodent models. This study provides a novel strategy for fabricating pH-responsive hydrogels, which may serve as a competent candidate for metabolism disorder management.
- Subjects :
- Adhesives
Animals
Drug Delivery Systems
Glucose Tolerance Test
Hydrogels chemical synthesis
Hydrogels chemistry
Hydrogen-Ion Concentration
Hydroxides chemistry
Materials Testing
Mice
Molecular Structure
Optical Imaging
Pectins chemical synthesis
Pectins chemistry
Sucralfate chemical synthesis
Sucralfate chemistry
Glucose Metabolism Disorders prevention & control
Hydrogels pharmacology
Hydroxides pharmacology
Pectins pharmacology
Sucralfate pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 13
- Issue :
- 49
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 34871495
- Full Text :
- https://doi.org/10.1021/acsami.1c17706