Synthesis of Azacarbolines via PhIO 2 -Promoted Intramolecular Oxidative Cyclization of α-Indolylhydrazones.

Authors :: Corrieri M
De Crescentini L
Mantellini F
Mari G
Santeusanio S
Favi G
Source :: The Journal of organic chemistry [J Org Chem] 2021 Dec 17; Vol. 86 (24), pp. 17918-17929. Date of Electronic Publication: 2021 Dec 06.
Publication Year :: 2021
Abstract: An unprecedented synthesis of polysubstituted indole-fused pyridazines (azacarbolines) from α-indolylhydrazones under oxidative conditions using a combination of iodylbenzene (PhIO <subscript>2</subscript> ) and trifluoroacetic acid (TFA) has been developed. This transformation is conducted without the need for transition metals, harsh conditions, or an inert atmosphere.

Subjects :: Cyclization
Oxidation-Reduction
Trifluoroacetic Acid
Oxidative Stress

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