The influence of immune status on the in vitro sensitivity of serotoninergic receptors in the rat stomach strip.

Authors :: Kadlec O
Masek K
Zídek Z
Source :: Methods and findings in experimental and clinical pharmacology [Methods Find Exp Clin Pharmacol] 1986 Feb; Vol. 8 (2), pp. 127-9.
Publication Year :: 1986
Abstract: Serotoninergic contractions of the rat stomach strip were evoked and EC50 determined. In preparations from control animals MDP, 50 mumol/l, decreased EC50 or sensitized the preparation. In the strips from animals where adjuvant arthritis was induced, higher sensitivity to 5-HT was observed and the sensitizing effect of MDP was retained. In the strips from animals pretreated with cyclophosphamide or in the terminal stage of tumor growth lower sensitivity to 5-HT, which could be further decreased by MDP, were noticed. These opposite effects in serotoninergic reactions were tentatively linked with the modulation of the immune status in vivo.

Subjects :: Animals
In Vitro Techniques
Male
Muscle Contraction drug effects
Muscle, Smooth drug effects
Rats
Rats, Inbred Lew
Serotonin pharmacology
Stomach drug effects
Acetylmuramyl-Alanyl-Isoglutamine pharmacology
Cyclophosphamide pharmacology
Freund's Adjuvant pharmacology
Receptors, Serotonin drug effects

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