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Sunscreen filter octocrylene is a potential obesogen by acting as a PPARγ partial agonist.
- Source :
-
Toxicology letters [Toxicol Lett] 2022 Feb 01; Vol. 355, pp. 141-149. Date of Electronic Publication: 2021 Dec 03. - Publication Year :
- 2022
-
Abstract
- Octocrylene (OC) is an extensively prescribed organic ultraviolet B filter used in sunscreen products. Due to its extensive use, a significant level of OC is detected in marine and freshwater environments. Notably, the bioaccumulation of OC in aquatic biota may affect human health. In this study, the effect of OC on metabolism was investigated using the adipogenesis model of human bone marrow mesenchymal stem cells (hBM-MSCs). OC promoted adiponectin production during adipogenesis in hBM-MSCs compared to the vehicle-treated control (EC <subscript>50</subscript> , 29.6 μM). In target identification, OC directly bound to peroxisome proliferator-activated receptor (PPAR) γ (Ki, 37.8 μM). OC-bound PPARγ also significantly recruited nuclear receptor coactivator proteins SRC-1 (EC <subscript>50</subscript> , 54.1 μM) and SRC-2 (EC <subscript>50</subscript> , 58.6 μM). In the molecular docking simulation study, the optimal ligand-binding mode of OC suggested that OC is a PPARγ partial agonist. A competitive analysis with a PPARγ full agonist pioglitazone revealed that OC acted as a PPARγ partial agonist. OC altered the gene transcription profile of lipid-metabolism associated enzymes in normal human keratinocytes, primarily exposed human cells after the application of sunscreens. In conclusion, OC is a potential metabolic disrupting obesogen.<br />Competing Interests: Declaration of Competing Interest The authors report no declarations of interest.<br /> (Copyright © 2021. Published by Elsevier B.V.)
- Subjects :
- Adipocytes drug effects
Bone Marrow Cells physiology
Catalytic Domain
Gene Expression Regulation drug effects
Humans
Keratinocytes drug effects
Lipid Metabolism
Models, Molecular
Molecular Docking Simulation
Molecular Structure
Nuclear Receptor Coactivator 1 genetics
Nuclear Receptor Coactivator 1 metabolism
Nuclear Receptor Coactivator 2 genetics
Nuclear Receptor Coactivator 2 metabolism
Protein Conformation
Acrylates toxicity
Adipocytes physiology
Bone Marrow Cells drug effects
Mesenchymal Stem Cells drug effects
Obesity chemically induced
PPAR gamma agonists
Subjects
Details
- Language :
- English
- ISSN :
- 1879-3169
- Volume :
- 355
- Database :
- MEDLINE
- Journal :
- Toxicology letters
- Publication Type :
- Academic Journal
- Accession number :
- 34864131
- Full Text :
- https://doi.org/10.1016/j.toxlet.2021.12.001