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The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: A randomized controlled trial.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2022 Jan 05; Vol. 914, pp. 174615. Date of Electronic Publication: 2021 Dec 02. - Publication Year :
- 2022
-
Abstract
- In this study, the therapeutic efficacy of quercetin in combination with remdesivir and favipiravir, were evaluated in severe hospitalized COVID-19 patients. Our main objective was to assess the ability of quercetin for preventing the progression of the disease into critical phase, and reducing the levels of inflammatory markers related to SARS-Cov-2 pathogenesis. Through an open-label clinical trial, 60 severe cases were randomly divided into control and intervention groups. During a 7-day period, patients in the control group received antivirals, i.e., remdesivir or favipiravir, while the intervention group was treated with 1000 mg of quercetin daily in addition to the antiviral drugs. According to the results, taking quercetin was significantly associated with partial earlier discharge and reduced serum levels of ALP, q-CRP, and LDH in the intervention group. Furthermore, although the values were in normal range, the statistical outputs showed significant increase in hemoglobin level and respiratory rate in patients who were taking quercetin. Based on our observations, quercetin is safe and effective in lowering the serum levels of ALP, q-CRP, and LDH as critical markers involved in COVID-19 severity. However, according to the non-significant borderline results in comparing the mortality, the ICU-admission rate, and the duration of ICU-admission, further studies can be helpful to compensate the limitations of our study and clarify the therapeutic potential of quercetin in COVID-19 treatments.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Subjects :
- Adenosine Monophosphate administration & dosage
Adenosine Monophosphate adverse effects
Alanine administration & dosage
Alanine adverse effects
Antioxidants administration & dosage
Antioxidants adverse effects
Antiviral Agents administration & dosage
Antiviral Agents adverse effects
Biomarkers blood
Drug Monitoring methods
Drug Monitoring statistics & numerical data
Female
Hemoglobins analysis
Humans
Male
Middle Aged
Outcome and Process Assessment, Health Care
Patient Discharge statistics & numerical data
Respiratory Rate drug effects
Adenosine Monophosphate analogs & derivatives
Alanine analogs & derivatives
Amides administration & dosage
Amides adverse effects
COVID-19 diagnosis
COVID-19 immunology
COVID-19 mortality
Pyrazines administration & dosage
Pyrazines adverse effects
Quercetin administration & dosage
Quercetin adverse effects
COVID-19 Drug Treatment
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0712
- Volume :
- 914
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 34863994
- Full Text :
- https://doi.org/10.1016/j.ejphar.2021.174615