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Vitamin E supplementation in hemodialysis patients: effects on peripheral blood mononuclear cells lipid peroxidation and immune response.
- Source :
-
Clinical nephrology [Clin Nephrol] 1986 Feb; Vol. 25 (2), pp. 81-6. - Publication Year :
- 1986
-
Abstract
- Lipid peroxidation and vitamin E levels in peripheral blood mononuclear cells (PBMC) were studied in 10 patients on maintenance hemodialysis. Significant increases of PBMC malonyldialdehyde (MDA) were detected, together with low vitamin E levels. After a fifteen-day-course of parenteral vitamin E supplementation, PBMC MDA reverted to normal values, while PBMC vitamin E levels remained lower than controls. In a parallel study an immunological monitoring was performed in the same patients before and after vitamin E supplementation. NK activity and PHA blastogenesis were not influenced by treatment, while a reduction of the number of OKT8+ lymphocytes were observed after vitamin E therapy. It is tempting to speculate that peroxidative damage of PBMC cell membranes in hemodialysis patients could, by impairing their functionality, influence immune responses and expression of functionally relevant membrane determinants.
- Subjects :
- Adult
Animals
Antibodies, Monoclonal immunology
Female
Humans
Killer Cells, Natural drug effects
Killer Cells, Natural immunology
Leukocyte Count drug effects
Lymphocyte Activation
Male
Malondialdehyde blood
Middle Aged
Phytohemagglutinins pharmacology
Rosette Formation
Sheep
T-Lymphocytes immunology
Uremia therapy
Vitamin E blood
Immunity, Cellular drug effects
Leukocytes drug effects
Lipid Peroxides blood
Renal Dialysis
Vitamin E pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0301-0430
- Volume :
- 25
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 3486074