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Spontaneous recurrent fetal wastage and autoimmune abnormalities: a study of fourteen cases.
- Source :
-
Clinical immunology and immunopathology [Clin Immunol Immunopathol] 1986 Jun; Vol. 39 (3), pp. 523-30. - Publication Year :
- 1986
-
Abstract
- Case records of 14 women with spontaneous recurrent fetal wastage were analyzed. Venous and/or arterial thrombosis developed in nine patients and vasospastic symptoms in eight. Every patient had some kind of autoantibodies: prothrombin activation inhibitor was present in seven cases, anticardiolipin in five, and, antimitochondrial antibodies in two. Antinuclear antibodies were present in seven cases, and significant titer of antibodies to single-stranded DNA in nine cases. With a mean follow up of 6.5 years no patient developed systemic lupus erythematosus. It is suggested that such women have a peculiar form of vasculitis.
- Subjects :
- Adult
Antibodies, Antinuclear analysis
Autoantibodies immunology
Cardiolipins immunology
Cell Nucleus immunology
DNA immunology
Female
Follow-Up Studies
Humans
Pregnancy
Prothrombin antagonists & inhibitors
Thrombosis complications
Abortion, Habitual immunology
Autoantibodies analysis
Autoimmune Diseases complications
Subjects
Details
- Language :
- English
- ISSN :
- 0090-1229
- Volume :
- 39
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical immunology and immunopathology
- Publication Type :
- Academic Journal
- Accession number :
- 3486073
- Full Text :
- https://doi.org/10.1016/0090-1229(86)90179-0