Epigenetic condensates regulate chromatin activity and tumorigenesis.

Authors :: Shi B
Li W
Jiang H
Source :: Molecular & cellular oncology [Mol Cell Oncol] 2021 Nov 09; Vol. 8 (5), pp. 1997040. Date of Electronic Publication: 2021 Nov 09 (Print Publication: 2021).
Publication Year :: 2021
Abstract: Alterations of epigenetic modulators are extensively associated with cancer, but their key molecular activities in cancer regulation are often unclear. We discovered that lysine demethylase 6A (KDM6A, also known as UTX) suppresses cancer by forming liquid-like condensates with lysine methyltransferase 2D (KMT2D, also known as MLL4) and regulating chromatin activity at multiple levels.<br />Competing Interests: No potential conflict of interest were disclosed.<br /> (© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.)