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Perfect adaptation of CD8 + T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation.

Authors :
Trendel N
Kruger P
Gaglione S
Nguyen J
Pettmann J
Sontag ED
Dushek O
Source :
Science signaling [Sci Signal] 2021 Jan 19; Vol. 14 (666), pp. eaay9363. Date of Electronic Publication: 2021 Jul 15.
Publication Year :
2021

Abstract

Reduced T cell responses by contrast antigen stimulation can be rescued by signals from costimulatory receptors.

Details

Language :
English
ISSN :
1937-9145
Volume :
14
Issue :
666
Database :
MEDLINE
Journal :
Science signaling
Publication Type :
Academic Journal
Accession number :
34855472
Full Text :
https://doi.org/10.1126/scisignal.aay9363