Back to Search
Start Over
The identification of the component in the inner membrane of brown adipose tissue mitochondria responsible for regulating energy dissipation.
- Source :
-
Experientia. Supplementum [Experientia Suppl] 1978; Vol. 32, pp. 89-93. - Publication Year :
- 1978
-
Abstract
- The proton conductance of the inner membrane of hamster brown adipose tissue mitochondria can be regulated in vitro by exogenous purine nucleotides, which bind to a component on the outer face of the inner membrane. This unique mechanism has been proposed to represent the molecular site of non-shivering thermogenesis in this tissue. Using a photo-affinity analogue of ATP, we have identified the nucleotide binding component as a protein of 32,000 daltons.
- Subjects :
- Adipose Tissue, Brown ultrastructure
Animals
Electric Conductivity
Electrophysiology
Membrane Proteins metabolism
Mitochondria ultrastructure
Protein Binding
Protons
Purine Nucleotides metabolism
Adipose Tissue, Brown metabolism
Energy Metabolism
Membrane Proteins physiology
Mitochondria metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0071-335X
- Volume :
- 32
- Database :
- MEDLINE
- Journal :
- Experientia. Supplementum
- Publication Type :
- Academic Journal
- Accession number :
- 348493
- Full Text :
- https://doi.org/10.1007/978-3-0348-5559-4_9