Back to Search
Start Over
Immunogenicity of SARS-CoV-2 vaccination in rituximab-treated patients: Effect of timing and immunologic parameters.
- Source :
-
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2022 Jan; Vol. 234, pp. 108897. Date of Electronic Publication: 2021 Nov 27. - Publication Year :
- 2022
-
Abstract
- Rituximab (RTX), an important therapeutic option for patients with rheumatic diseases, has been shown to reduce immune responses to various vaccines. We asked whether following SARS-CoV-2 vaccination, response rates in RTX treated patients are reduced and whether specific patient characteristics influence the responses. We recruited patients on chronic RTX therapy undergoing anti-SARS-CoV2 vaccination and measured the post-vaccination anti-spike IgG antibody levels. The median time from pre-vaccination RTX infusion to vaccination and from vaccination to the post-vaccination RTX infusion was 20.5 weeks and 7.2 weeks respectively. Only 36.5% of patients developed measurable titers of IgG anti-SARS-CoV-2 spike antibody after vaccination. Hypogammaglobulinemia (IgG and/or IgM) but not timing of vaccination, B cell numbers, or concomitant immune suppressive medications, correlated with sero-negativity (p = 0.004). Our results underscore the fact that even after B cell reconstitution, RTX induced chronic hypogammaglobulinemia significantly impairs the ability of the immune system to respond to SARS-CoV-2 vaccination.<br /> (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Subjects :
- Agammaglobulinemia immunology
Aged
Antibodies, Neutralizing immunology
Antibodies, Viral immunology
B-Lymphocytes immunology
Female
Humans
Immunoglobulin G immunology
Immunoglobulin M immunology
Male
Middle Aged
Prospective Studies
Rheumatic Diseases immunology
Vaccination methods
COVID-19 immunology
COVID-19 Vaccines immunology
Immunogenicity, Vaccine immunology
Rheumatic Diseases drug therapy
Rituximab therapeutic use
SARS-CoV-2 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1521-7035
- Volume :
- 234
- Database :
- MEDLINE
- Journal :
- Clinical immunology (Orlando, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 34848357
- Full Text :
- https://doi.org/10.1016/j.clim.2021.108897