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Pulmonary hypertension in infants with bronchopulmonary dysplasia: risk factors, mortality and duration of hospitalisation.
- Source :
-
Journal of perinatal medicine [J Perinat Med] 2021 Dec 01; Vol. 50 (3), pp. 327-333. Date of Electronic Publication: 2021 Dec 01 (Print Publication: 2022). - Publication Year :
- 2021
-
Abstract
- Objectives: Pulmonary hypertension (PH) is a complication of bronchopulmonary dysplasia (BPD) and associated with increased mortality and morbidity. Our aim was to identify, in infants with BPD, the effect of PH on health-care utilisation and health related cost of care.<br />Methods: An electronic data recording system was used to identify infants ≤32 weeks of gestation who developed BPD. PH was classified as early (≤28 days after birth) or late (>28 days after birth).<br />Results: In the study period, 182 infants developed BPD; 22 (12.1%) developed late PH. Development of late PH was associated with a lower gestational age [24.6 (23.9-26.9) weeks, p=0.001] and a greater need for positive pressure ventilation on day 28 after birth (100%) compared to infants without late PH (51.9%) (odds ratio (OR) 19.5, 95% CI: 2.6-148), p<0.001. Late PH was associated with increased mortality (36.4%) compared those who did not develop late PH (1.9%) after adjusting for gestational age and ventilation duration (OR: 26.9, 95% CI: 3.8-189.4), p<0.001. In infants who survived to discharge, late PH development was associated with a prolonged duration of stay [147 (118-189) days] compared to the infants that did not develop late PH [109 (85-149) days] (p=0.03 after adjusting for gestational age). Infants who had late PH had a higher cost of stay compared to infants with BPD who did not develop late PH (median £113,494 vs. £78,677, p=0.016 after adjusting for gestational age).<br />Conclusions: Development of late PH was associated with increased mortality, a prolonged duration of stay and higher healthcare cost.<br /> (© 2021 Fahad M.S. Arattu Thodika et al., published by De Gruyter, Berlin/Boston.)
- Subjects :
- Birth Weight
Female
Hospital Costs
Humans
Hypertension, Pulmonary economics
Infant
Infant, Newborn
Infant, Premature
Intensive Care Units, Neonatal economics
Length of Stay
London epidemiology
Male
Respiration, Artificial
Risk Factors
Bronchopulmonary Dysplasia epidemiology
Hypertension, Pulmonary epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1619-3997
- Volume :
- 50
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of perinatal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 34847313
- Full Text :
- https://doi.org/10.1515/jpm-2021-0366