COVID-19 vaccinations: The unknowns, challenges, and hopes.

Authors :: Mohamed K
Rzymski P
Islam MS
Makuku R
Mushtaq A
Khan A
Ivanovska M
Makka SA
Hashem F
Marquez L
Cseprekal O
Filgueiras IS
Fonseca DLM
Mickael E
Ling I
Arero AG
Cuschieri S
Minakova K
Rodríguez-Román E
Abarikwu SO
Faten AB
Grancini G
Cabral-Marques O
Rezaei N
Source :: Journal of medical virology [J Med Virol] 2022 Apr; Vol. 94 (4), pp. 1336-1349. Date of Electronic Publication: 2021 Dec 10.
Publication Year :: 2022
Abstract: The entire world has been suffering from the coronavirus disease 2019 (COVID-19) pandemic since March 11, 2020. More than a year later, the COVID-19 vaccination brought hope to control this viral pandemic. Here, we review the unknowns of the COVID-19 vaccination, such as its longevity, asymptomatic spread, long-term side effects, and its efficacy on immunocompromised patients. In addition, we discuss challenges associated with the COVID-19 vaccination, such as the global access and distribution of vaccine doses, adherence to hygiene guidelines after vaccination, the emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, and vaccine resistance. Despite all these challenges and the fact that the end of the COVID-19 pandemic is still unclear, vaccines have brought great hope for the world, with several reports indicating a significant decline in the risk of COVID19-related infection and hospitalizations.<br /> (© 2021 Wiley Periodicals LLC.)