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Solving the puzzle of Fe homeostasis by integrating molecular, mathematical, and societal models.
- Source :
-
Current opinion in plant biology [Curr Opin Plant Biol] 2021 Dec; Vol. 64, pp. 102149. Date of Electronic Publication: 2021 Nov 25. - Publication Year :
- 2021
-
Abstract
- To ensure optimal utilization and bioavailability, iron uptake, transport, subcellular localization, and assimilation are tightly regulated in plants. Herein, we examine recent advances in our understanding of cellular responses to Fe deficiency. We then use intracellular mechanisms of Fe homeostasis to discuss how formalizing cell biology knowledge via a mathematical model can advance discovery even when quantitative data is limited. Using simulation-based inference to identify plausible systems mechanisms that conform to known emergent phenotypes can yield novel, testable hypotheses to guide targeted experiments. However, this approach relies on the accurate encoding of domain-expert knowledge in exploratory mathematical models. We argue that this would be facilitated by fostering more "systems thinking" life scientists and that diversifying your research team may be a practical path to achieve that goal.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-0356
- Volume :
- 64
- Database :
- MEDLINE
- Journal :
- Current opinion in plant biology
- Publication Type :
- Academic Journal
- Accession number :
- 34839201
- Full Text :
- https://doi.org/10.1016/j.pbi.2021.102149