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Human milk oligosaccharides and infant gut microbiota: Molecular structures, utilization strategies and immune function.

Authors :
Zhang B
Li LQ
Liu F
Wu JY
Source :
Carbohydrate polymers [Carbohydr Polym] 2022 Jan 15; Vol. 276, pp. 118738. Date of Electronic Publication: 2021 Oct 09.
Publication Year :
2022

Abstract

Human milk oligosaccharides (HMOs) are a unique class of non-digestible carbohydrates present in the mother milk, which play a key role in the development of infant gut microbiota, epithelial barrier and immune function. The deficiency of HMOs in the bovine milk-based infant formula has been widely recognized as a major culprit for the much higher incidence of immune disorders of formula-fed infants. This report was to give an up-to-date review on the structure characteristics of HMOs and the possible mechanisms, and strategies for their cellular uptake, and metabolism by the gut bacteria and the associated effects on the infant gut microbiome, and immune function. Most previous studies have been carried out in animals or in vitro model systems on the utilization strategies for HMOs in infant bacteria and their roles in infant microbiome, and gut immune function. A few HMO molecules have been synthesized artificially and applied in infant formulas.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1879-1344
Volume :
276
Database :
MEDLINE
Journal :
Carbohydrate polymers
Publication Type :
Academic Journal
Accession number :
34823774
Full Text :
https://doi.org/10.1016/j.carbpol.2021.118738