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Comparison of the immunogenicity of BNT162b2 and CoronaVac COVID-19 vaccines in Hong Kong.
- Source :
-
Respirology (Carlton, Vic.) [Respirology] 2022 Apr; Vol. 27 (4), pp. 301-310. Date of Electronic Publication: 2021 Nov 24. - Publication Year :
- 2022
-
Abstract
- Background and Objective: Few head-to-head evaluations of immune responses to different vaccines have been reported.<br />Methods: Surrogate virus neutralization test (sVNT) antibody levels of adults receiving either two doses of BNT162b2 (n = 366) or CoronaVac (n = 360) vaccines in Hong Kong were determined. An age-matched subgroup (BNT162b2 [n = 49] vs. CoronaVac [n = 49]) was tested for plaque reduction neutralization (PRNT) and spike-binding antibody and T-cell reactivity in peripheral blood mononuclear cells.<br />Results: One month after the second dose of vaccine, BNT162b2 elicited significantly higher PRNT <subscript>50</subscript> , PRNT <subscript>90</subscript> , sVNT, spike receptor binding, spike N-terminal domain binding, spike S2 domain binding, spike FcR binding and antibody avidity levels than CoronaVac. The geometric mean PRNT <subscript>50</subscript> titres in those vaccinated with BNT162b2 and CoronaVac vaccines were 251.6 and 69.45, while PRNT <subscript>90</subscript> titres were 98.91 and 16.57, respectively. All of those vaccinated with BNT162b2 and 45 (91.8%) of 49 vaccinated with CoronaVac achieved the 50% protection threshold for PRNT <subscript>90.</subscript> Allowing for an expected seven-fold waning of antibody titres over 6 months for those receiving CoronaVac, only 16.3% would meet the 50% protection threshold versus 79.6% of BNT162b2 vaccinees. Age was negatively correlated with PRNT <subscript>90</subscript> antibody titres. Both vaccines induced SARS-CoV-2-specific CD4 <superscript>+</superscript> and CD8 <superscript>+</superscript> T-cell responses at 1 month post-vaccination but CoronaVac elicited significantly higher structural protein-specific CD4 <superscript>+</superscript> and CD8 <superscript>+</superscript> T-cell responses.<br />Conclusion: Vaccination with BNT162b2 induces stronger humoral responses than CoronaVac. CoronaVac induces higher CD4 <superscript>+</superscript> and CD8 <superscript>+</superscript> T-cell responses to the structural protein than BNT162b2.<br /> (© 2021 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology.)
Details
- Language :
- English
- ISSN :
- 1440-1843
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Respirology (Carlton, Vic.)
- Publication Type :
- Academic Journal
- Accession number :
- 34820940
- Full Text :
- https://doi.org/10.1111/resp.14191