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Backbone 1 H, 15 N, and 13 C resonance assignments of the non-structural protein NS2B of Zika virus.
- Source :
-
Biomolecular NMR assignments [Biomol NMR Assign] 2022 Apr; Vol. 16 (1), pp. 31-35. Date of Electronic Publication: 2021 Nov 24. - Publication Year :
- 2022
-
Abstract
- Zika virus (ZIKV) emerged as a global public health concern due to its relationship with severe neurological disorders. Non-structural (NS) proteins of ZIKV are essential for viral replication, regulatory function, and subversion of host responses. NS2B is a membrane protein responsible for the regulation of viral protease activity. This protein has transmembrane domains critical for the localization of viral protease to the endoplasmic reticulum membrane and a hydrophilic domain essential for folding, recruitment, and protease activity. Therefore, NS2B is considered a cofactor of viral protease which processes viral polyprotein and is essential for virus replication, making it an attractive antiviral drug target. Here, we report the backbone <superscript>1</superscript> H, <superscript>15</superscript> N, <superscript>13</superscript> C resonance assignments of the full-length NS2B by high-resolution NMR. The backbone assignment will be necessary for determining the three-dimensional structure and backbone dynamics of NS2B, interaction mapping and screening potential of antiviral drugs against ZIKV and related pathogenic flaviviruses.<br /> (© 2021. The Author(s), under exclusive licence to Springer Nature B.V.)
Details
- Language :
- English
- ISSN :
- 1874-270X
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biomolecular NMR assignments
- Publication Type :
- Academic Journal
- Accession number :
- 34817802
- Full Text :
- https://doi.org/10.1007/s12104-021-10055-2