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Steady-state kinetics of the quinolone derivatives ofloxacin, enoxacin, ciprofloxacin and pefloxacin during maintenance treatment with theophylline.
- Source :
-
Drugs [Drugs] 1987; Vol. 34 Suppl 1, pp. 159-69. - Publication Year :
- 1987
-
Abstract
- Some of the new quinolone derivatives may be of value in the treatment of respiratory tract infections. It has been demonstrated that enoxacin, pefloxacin and ciprofloxacin, but not ofloxacin, decreased the metabolic clearance of the bronchodilator theophylline. This resulted in elevated plasma theophylline concentrations and, in some of the patients, theophylline toxicity. When the pharmacokinetic parameters of enoxacin, pefloxacin, ciprofloxacin and ofloxacin obtained in the present study were compared with those obtained from other studies in healthy volunteers not given concomitant theophylline, there was no evidence of theophylline influencing the clearance of the investigated quinolones.
- Subjects :
- Aged
Ciprofloxacin pharmacokinetics
Drug Interactions
Enoxacin
Female
Humans
Male
Middle Aged
Naphthyridines pharmacokinetics
Norfloxacin analogs & derivatives
Norfloxacin pharmacokinetics
Ofloxacin
Pefloxacin
Anti-Infective Agents pharmacokinetics
Oxazines pharmacokinetics
Quinolines pharmacokinetics
Theophylline adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0012-6667
- Volume :
- 34 Suppl 1
- Database :
- MEDLINE
- Journal :
- Drugs
- Publication Type :
- Academic Journal
- Accession number :
- 3481317
- Full Text :
- https://doi.org/10.2165/00003495-198700341-00034