Back to Search
Start Over
pH-Responsive Multifunctional Theranostic Rapamycin-Loaded Nanoparticles for Imaging and Treatment of Acute Ischemic Stroke.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Dec 08; Vol. 13 (48), pp. 56909-56922. Date of Electronic Publication: 2021 Nov 22. - Publication Year :
- 2021
-
Abstract
- Stroke is the second leading cause of death globally and the most common cause of severe disability. Several barriers need to be addressed more effectively to treat stroke, including efficient delivery of therapeutic agents, rapid release at the infarct site, precise imaging of the infarct site, and drug distribution monitoring. The present study aimed to develop a bio-responsive theranostic nanoplatform with signal-amplifying capability to deliver rapamycin (RAPA) to ischemic brain tissues and visually monitor drug distribution. A pH-sensitive theranostic RAPA-loaded nanoparticle system was designed since ischemic tissues have a low-pH microenvironment compared with normal tissues. The nanoparticles demonstrated good stability and biocompatibility and could efficiently load rapamycin, followed by its rapid release in acidic environments, thereby improving therapeutic accuracy. The nano-drug-delivery system also exhibited acid-enhanced magnetic resonance imaging (MRI) and near-infrared fluorescence (NIRF) imaging signal properties, enabling accurate multimodal imaging with minimal background noise, thus improving drug tracing and diagnostic accuracy. Finally, in vivo experiments confirmed that the nanoparticles preferentially aggregated in the ischemic hemisphere and exerted a neuroprotective effect in rats with transient middle cerebral artery occlusion (tMCAO). These pH-sensitive multifunctional theranostic nanoparticles could serve as a potential nanoplatform for drug tracing as well as the treatment and even diagnosis of acute ischemic stroke. Moreover, they could be a universal solution to achieve accurate in vivo imaging and treatment of other diseases.
- Subjects :
- Acute Disease
Animals
Biomimetic Materials chemistry
Hydrogen-Ion Concentration
Ischemic Stroke diagnostic imaging
Materials Testing
Neuroprotective Agents chemistry
PC12 Cells
Particle Size
Rats
Sirolimus chemistry
Biomimetic Materials therapeutic use
Ischemic Stroke drug therapy
Nanoparticles chemistry
Neuroprotective Agents therapeutic use
Sirolimus therapeutic use
Theranostic Nanomedicine
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 13
- Issue :
- 48
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 34807583
- Full Text :
- https://doi.org/10.1021/acsami.1c16530