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Biodegradable Hollow Polydopamine@manganese Dioxide as an Oxygen Self-Supplied Nanoplatform for Boosting Chemo-photodynamic Cancer Therapy.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Dec 08; Vol. 13 (48), pp. 57009-57022. Date of Electronic Publication: 2021 Nov 22. - Publication Year :
- 2021
-
Abstract
- Photodynamic therapy (PDT) has attracted extensive attention in the clinical treatment of malignant tumor. However, the acidic and hypoxic conditions of the tumor microenvironment (TME) limit the further application of PDT in the clinic. Herein, we fabricate a new nanoplatform─HPDA@MnO <subscript>2</subscript> @Ce6/DOX@PEG-RGD (HPMRCD)─by means of coating hollow polydopamine nanoparticles (HPDA) with manganese dioxide (MnO <subscript>2</subscript> ), which is modified by cyclic RGD functionalized poly(ethylene glycol) (PEG) and further co-loaded with a photosensitizer, Chlorin e6 (Ce6), and a chemotherapy drug, doxorubicin (DOX). This nanoplatform could be enriched in tumor tissues, then instantly dissociated under an acidic and H <subscript>2</subscript> O <subscript>2</subscript> -rich TME. The dual-responsive release of Mn <superscript>2+</superscript> ions and oxygen (O <subscript>2</subscript> ) can relieve tumor hypoxia, which can be used as a magnetic resonance contrast agent and the latter can enhance the PDT effect. Furthermore, the degradation of HPMRCD leads to an efficient loaded therapeutic molecule release, thus yielding a potential therapy to enhance tumor suppression by adopting the combined chemo-photodynamic therapy.
- Subjects :
- Animals
Antibiotics, Antineoplastic chemistry
Apoptosis drug effects
Biomimetic Materials chemical synthesis
Biomimetic Materials chemistry
Cell Line, Tumor
Cell Proliferation drug effects
Cell Survival drug effects
Doxorubicin chemistry
Drug Liberation
Drug Screening Assays, Antitumor
Female
Indoles chemistry
Indoles pharmacology
Manganese Compounds chemistry
Manganese Compounds pharmacology
Materials Testing
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasms, Experimental drug therapy
Neoplasms, Experimental metabolism
Neoplasms, Experimental pathology
Oxides chemistry
Oxides pharmacology
Oxygen chemistry
Particle Size
Polymers chemistry
Polymers pharmacology
Porosity
Antibiotics, Antineoplastic pharmacology
Biomimetic Materials pharmacology
Doxorubicin pharmacology
Nanoparticles chemistry
Oxygen pharmacology
Photochemotherapy
Tumor Hypoxia drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 13
- Issue :
- 48
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 34806877
- Full Text :
- https://doi.org/10.1021/acsami.1c18601