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Unexpected cause of vemurafenib-induced nephrotoxicity: ferrochelatase.
- Source :
-
Kidney international [Kidney Int] 2021 Dec; Vol. 100 (6), pp. 1158-1160. - Publication Year :
- 2021
-
Abstract
- Among v-raf murine sarcoma viral oncogene homolog B1 inhibitors, vemurafenib causes a higher incidence of nephrotoxicity. Bai et al. reported that vemurafenib-induced nephrotoxicity is not directly caused by viral oncogene homolog B1 inhibition but is partly caused by ferrochelatase inhibition in renal tubular epithelial cells. Because several other protein kinase inhibitors are also known to cause ferrochelatase inhibition, further studies are needed to elucidate the role of ferrochelatase in renal function and injury.<br /> (Copyright © 2021 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1523-1755
- Volume :
- 100
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Kidney international
- Publication Type :
- Academic Journal
- Accession number :
- 34802553
- Full Text :
- https://doi.org/10.1016/j.kint.2021.09.010