A Micro-Environment Regulator for Filling the Clinical Treatment Gap after a Glioblastoma Operation.

Authors :: Zhang Y
You H
Wang Y
Chen Q
Guo Q
Chu Y
Li C
Zhou W
Chen H
Liu P
Wang Y
Zhao Z
Zhou Z
Luo Y
Li X
Zhang T
Song H
Li C
Su B
Sun T
Bi Y
Yu L
Jiang C
Source :: Advanced healthcare materials [Adv Healthc Mater] 2022 Feb; Vol. 11 (3), pp. e2101578. Date of Electronic Publication: 2022 Jan 07.
Publication Year :: 2022
Abstract: The rapid postoperative recurrence and short survival time of glioblastoma (GBM) patients necessitate immediate and effective postoperative treatment. Herein, an immediate and mild postoperative local treatment strategy is developed that regulates the postoperative microenvironment and delays GBM recurrence. Briefly, an injectable hydrogel system (imGEL) loaded with Zn(II) <subscript>2</subscript> -AMD3100 (AMD-Zn) and CpG oligonucleotide nanoparticles (CpG NPs) is injected into the operation cavity, with long-term function to block the recruitment of microglia/ macrophages and activate cytotoxic T cells. The finding indicated that the imGEL can regulate the immune microenvironment, inhibit GBM recurrence, and gain valuable time for subsequent adjuvant clinical chemotherapy.<br /> (© 2022 Wiley-VCH GmbH.)

Subjects :: Cell Line, Tumor
Humans
Hydrogels therapeutic use
Tumor Microenvironment
Brain Neoplasms drug therapy
Brain Neoplasms surgery
Glioblastoma drug therapy
Glioblastoma surgery
Nanoparticles therapeutic use

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