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Protective effect of quercetin against the metabolic dysfunction of glucose and lipids and its associated learning and memory impairments in NAFLD rats.
- Source :
-
Lipids in health and disease [Lipids Health Dis] 2021 Nov 17; Vol. 20 (1), pp. 164. Date of Electronic Publication: 2021 Nov 17. - Publication Year :
- 2021
-
Abstract
- Background: Quercetin (QUE) is a flavonol reported with anti-inflammatory and antioxidant activities, and previous results from the group of this study have demonstrated its neuroprotective effect against lipopolysaccharide-induced neuropsychiatric injuries. However, little is known about its potential effect on neuropsychiatric injuries induced or accompanied by metabolic dysfunction of glucose and lipids.<br />Methods: A nonalcoholic fatty liver disease (NAFLD) rat model was induced via a high-fat diet (HFD), and glucolipid parameters and liver function were measured. Behavioral performance was observed via the open field test (OFT) and the Morris water maze (MWM). The plasma levels of triggering receptor expressed on myeloid cells-1 (TREM1) and TREM2 were measured via enzyme-linked immunosorbent assay (ELISA). The protein expression levels of Synapsin-1 (Syn-1), Synaptatogmin-1 (Syt-1), TREM1 and TREM2 in the hippocampus were detected using western blotting. Morphological changes in the liver and hippocampus were detected by HE and Oil red or silver staining.<br />Results: Compared with the control rats, HFD-induced NAFLD model rats presented significant metabolic dysfunction, hepatocyte steatosis, and impaired learning and memory ability, as indicated by the increased plasma concentrations of total cholesterol (TC) and triglyceride (TG), the impaired glucose tolerance, the accumulated fat droplets and balloon-like changes in the liver, and the increased escaping latency but decreased duration in the target quadrant in the Morris water maze. All these changes were reversed in QUE-treated rats. Moreover, apart from improving the morphological injuries in the hippocampus, treatment with QUE could increase the decreased plasma concentration and hippocampal protein expression of TREM1 in NAFLD rats and increase the decreased expression of Syn-1 and Syt-1 in the hippocampus.<br />Conclusions: These results suggested the therapeutic potential of QUE against NAFLD-associated impairment of learning and memory, and the mechanism might involve regulating the metabolic dysfunction of glucose and lipids and balancing the protein expression of synaptic plasticity markers and TREM1/2 in the hippocampus.<br /> (© 2021. The Author(s).)
- Subjects :
- Animals
Blotting, Western
Disease Models, Animal
Glucose Tolerance Test
Liver pathology
Male
Membrane Glycoproteins blood
Memory Disorders etiology
Metabolic Diseases etiology
Morris Water Maze Test drug effects
Non-alcoholic Fatty Liver Disease complications
Open Field Test drug effects
Rats
Rats, Sprague-Dawley
Receptors, Immunologic blood
Triggering Receptor Expressed on Myeloid Cells-1 blood
Memory Disorders drug therapy
Metabolic Diseases drug therapy
Neuroprotective Agents therapeutic use
Non-alcoholic Fatty Liver Disease drug therapy
Quercetin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1476-511X
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Lipids in health and disease
- Publication Type :
- Academic Journal
- Accession number :
- 34789244
- Full Text :
- https://doi.org/10.1186/s12944-021-01590-x