Three New Hydroxyphenylacetic Acid Derivatives and A New Alkaloid from Endophytic Fungus Mortierella sp. in Epimedium acuminatum Franch. and Their Antibacterial Activity.

Authors :: Huang ZD
Wang WJ
Han XL
Yang XL
Source :: Chemistry & biodiversity [Chem Biodivers] 2021 Dec; Vol. 18 (12), pp. e2100741. Date of Electronic Publication: 2021 Nov 16.
Publication Year :: 2021
Abstract: Three new hydroxyphenylacetic acid derivatives, stachylines E-G (1-3), and a new alkaloid, mortieridinone (4), along with six known compounds (5-10), were isolated from endophytic fungus Mortierella sp. in Epimedium acuminatum Franch. Their structures were determined by their spectroscopic analyses and by comparison with the literature data. Compounds 7 and 10 showed selective antibacterial activity against tested multidrug-resistant bacteria with minimum inhibitory concentration (MIC) values ranging from 25 to 3.13 μg/mL.<br /> (© 2021 Wiley-VHCA AG, Zurich, Switzerland.)

Subjects :: Alkaloids chemistry
Alkaloids isolation & purification
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents isolation & purification
Drug Resistance, Multiple, Bacterial drug effects
Enterococcus faecium drug effects
Microbial Sensitivity Tests
Molecular Structure
Phenylacetates chemistry
Phenylacetates isolation & purification
Staphylococcus aureus drug effects
Alkaloids pharmacology
Anti-Bacterial Agents pharmacology
Epimedium microbiology
Mortierella chemistry
Phenylacetates pharmacology

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