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How much time is enough? Sentinel lymph node mapping time depends on the radiotracer agent.
- Source :
-
Journal of surgical oncology [J Surg Oncol] 2022 Mar; Vol. 125 (4), pp. 712-718. Date of Electronic Publication: 2021 Nov 17. - Publication Year :
- 2022
-
Abstract
- Background: In 2014, technetium-99m tilmanocept (TcTM) replaced technetium-99m sulfur colloid (TcSC) as the standard lymphoscintigraphy (LS) mapping agent in melanoma patients undergoing sentinel lymph node biopsy (SLNB). The aim of this study was to examine differences in mapping time, intra-operative identification of sentinel lymph node (SLN), and false negative rate (FNR) between patients who underwent SLNB with TcTM compared to TcSC.<br />Methods: Patients who underwent SLNB between 2010 and 2018 were retrospectively identified. Patient demographic, tumor, and imaging data was stratified by receipt of TcSC (n = 258) or TcTM (n = 133). Student's t test and χ <superscript>2</superscript> test were used to compare characteristics and outcomes.<br />Results: Both cohorts were similar in demographic, primary tumor characteristics, and total number of SLN identified (TcTM 3.56 vs. TcSC 3.28, p = 0.244). TcTM was associated with significantly shorter LS mapping times (51.8 vs. 195.1 min, p < 0.01). There was no significant difference in the number of patients with positive SLN (TcTM 11.3 vs. TcSC 17.4%, p = 0.109) and the FNR was similar between both groups (TcTM 25% vs. TcSC 22%).<br />Conclusion: TcTM was associated with significantly shorter LS mapping time while identifying similar numbers of SLN. Our results support further study to ensure similar FNR and oncologic outcomes between agents.<br /> (© 2021 Wiley Periodicals LLC.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Female
Follow-Up Studies
Humans
Male
Melanoma diagnostic imaging
Melanoma metabolism
Melanoma surgery
Middle Aged
Neoplasm Recurrence, Local diagnostic imaging
Neoplasm Recurrence, Local metabolism
Neoplasm Recurrence, Local surgery
Prognosis
Retrospective Studies
Sentinel Lymph Node diagnostic imaging
Sentinel Lymph Node metabolism
Sentinel Lymph Node surgery
Sentinel Lymph Node Biopsy
Young Adult
Lymphoscintigraphy methods
Melanoma pathology
Neoplasm Recurrence, Local pathology
Radiopharmaceuticals metabolism
Sentinel Lymph Node pathology
Technetium Tc 99m Pentetate metabolism
Technetium Tc 99m Sulfur Colloid metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1096-9098
- Volume :
- 125
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 34786720
- Full Text :
- https://doi.org/10.1002/jso.26752