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Synchronous diagnosis and treatment of acute myeloid leukemia and chronic lymphocytic leukemia: Two case reports.

Authors :
Chen RR
Zhu LX
Wang LL
Li XY
Sun JN
Xie MX
Zhu JJ
Zhou
Li JH
Huang X
Xie WZ
Ye XJ
Source :
World journal of clinical cases [World J Clin Cases] 2021 Oct 26; Vol. 9 (30), pp. 9144-9150.
Publication Year :
2021

Abstract

Background: The concurrence of acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL) is rare. Previous reports of such cases have focused mainly on clinical diagnosis and characteristics, so the mechanism remains unclear, and therapy options have been poorly explored.<br />Case Summary: Here, we report two cases of synchronous AML and CLL. Flow cytometry revealed two distinct abnormal cell populations (myeloblasts and lymphoid cells) according to scatter characteristics. CD5-positive B cell lymphoma with myeloid leukemia invasion was observed on lymph node biopsy. Chemotherapy regimens indicated for both AML and CLL were used in our patients, and our patients achieved complete response after chemotherapy. Next-generation sequencing of 88 genes was performed.<br />Conclusion: We conclude that early mutation and dysregulation at the hematopoietic stem cell stage and the accumulation of multiple rearrangements may cause the concurrence of CLL and AML. The treatment of infection and combination therapy aimed at the CLL component are significant in the management of patients with concurrent CLL and AML.<br />Competing Interests: Conflict-of-interest statement: The authors declare that they have no conflict of interest.<br /> (©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.)

Details

Language :
English
ISSN :
2307-8960
Volume :
9
Issue :
30
Database :
MEDLINE
Journal :
World journal of clinical cases
Publication Type :
Report
Accession number :
34786398
Full Text :
https://doi.org/10.12998/wjcc.v9.i30.9144