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Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.
- Source :
-
Die Pharmazie [Pharmazie] 2021 Nov 01; Vol. 76 (11), pp. 551-558. - Publication Year :
- 2021
-
Abstract
- Inflammation is an important pathological feature of hyperuricemia, which in turn aggravates hyperuricemia. Astaxanthin is a carotenoid with strong antioxidant capacity and possesses many biological activities. This study was aimed to evaluate the effect of astaxanthin (ASX) on hyperuricemia and kidney inflammation in potassium oxonate (PO) and hypoxanthine (HX)-induced hyperuricemic mice. Male ICR mice were administered intragastrically with PO and HX (250 mg/kg, respectively) for 14 days. ASX was given by gavage one hour after PO and HX administration. ASX treatment significantly reversed PO and HX-induced hyperuricemia and kidney inflammation in mice as evidenced by decreased serum levels of uric acid (UA), creatinine (Cr), blood urea nitrogen (BUN), and inflammatory factors (IL-1β, IL-6, and TNF-α) and increased activities of antioxidant enzymes (CAT, SOD and GSH-Px). Furthermore, ASX administration effectively inhibited the activities of key enzymes related to UA synthesis (xanthine oxidase (XOD) and adenosine deaminase (ADA)) and modulated the protein expressions of NF-κ B p65, p-NF-κ B p65, Iκ Bα, p-Iκ Bα, NLRP3, ASC, Caspase-1, and cleavedCaspase-1 involved in inflammation pathways. Our results suggested that ASX improved hyperuricemia and kidney inflammation induced by PO and HX, probably by reducing UA synthesis and suppressing the NF-κ B and NLRP3 pathways simultaneously.
- Subjects :
- Animals
Antioxidants pharmacology
Hypoxanthine adverse effects
Inflammation drug therapy
Inflammation pathology
Kidney metabolism
Male
Mice
Mice, Inbred ICR
NF-kappa B metabolism
NLR Family, Pyrin Domain-Containing 3 Protein metabolism
Oxonic Acid
Signal Transduction
Transcription Factor RelA metabolism
Uric Acid metabolism
Uric Acid pharmacology
Xanthine Oxidase adverse effects
Xanthine Oxidase metabolism
Xanthophylls
Hyperuricemia chemically induced
Hyperuricemia drug therapy
Hyperuricemia metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0031-7144
- Volume :
- 76
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Die Pharmazie
- Publication Type :
- Academic Journal
- Accession number :
- 34782040
- Full Text :
- https://doi.org/10.1691/ph.2021.1731