Synergistic Copper/Enamine Catalysis for the Regio-, Stereo-, and Enantioselective Intermolecular α-Addition of Aldehydes to Allenamides.

We herein describe an intermolecular enantioselective α-addition of aldehydes to allenamides using a dual copper/enamine catalytic system. Highly enantioselective addition of aldehydes was obtained thanks to secondary amine catalysts. The process was found to be highly regio-, stereo-, and enantioselective under mild conditions.