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The role of OncoSnoRNAs and Ribosomal RNA 2'-O-methylation in Cancer.

Authors :
Barros-Silva D
Klavert J
Jenster G
Jerónimo C
Lafontaine DLJ
Martens-Uzunova ES
Source :
RNA biology [RNA Biol] 2021 Oct 15; Vol. 18 (sup1), pp. 61-74. Date of Electronic Publication: 2021 Nov 14.
Publication Year :
2021

Abstract

Ribosomes are essential nanomachines responsible for all protein production in cells. Ribosome biogenesis and function are energy costly processes, they are tightly regulated to match cellular needs. In cancer, major pathways that control ribosome biogenesis and function are often deregulated to ensure cell survival and to accommodate the continuous proliferation of tumour cells. Ribosomal RNAs (rRNAs) are abundantly modified with 2'-O-methylation (Nm, ribomethylation) being one of the most common modifications. In eukaryotic ribosomes, ribomethylation is performed by the methyltransferase Fibrillarin guided by box C/D small nucleolar RNAs (snoRNAs). Accumulating evidences indicate that snoRNA expression and ribosome methylation profiles are altered in cancer. Here we review our current knowledge on differential snoRNA expression and rRNA 2'-O methylation in the context of human malignancies, and discuss the consequences and opportunities for cancer diagnostics, prognostics, and therapeutics.

Details

Language :
English
ISSN :
1555-8584
Volume :
18
Issue :
sup1
Database :
MEDLINE
Journal :
RNA biology
Publication Type :
Academic Journal
Accession number :
34775914
Full Text :
https://doi.org/10.1080/15476286.2021.1991167